N-methyl-D-aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse.
Identifieur interne : 000504 ( Main/Exploration ); précédent : 000503; suivant : 000505N-methyl-D-aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse.
Auteurs : Yael Hacohen [Royaume-Uni] ; Kumaran Deiva ; Phillipa Pettingill ; Patrick Waters ; Ata Siddiqui ; Pascale Chretien ; Esse Menson ; Jean-Pierre Lin ; Marc Tardieu ; Angela Vincent ; Ming J. LimSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- Adolescent, Anti-N-Methyl-D-Aspartate Receptor Encephalitis (blood), Anti-N-Methyl-D-Aspartate Receptor Encephalitis (immunology), Autoantibodies (blood), Child, Preschool, Encephalitis, Herpes Simplex (blood), Encephalitis, Herpes Simplex (immunology), Female, Humans, Infant, Male, Receptors, N-Methyl-D-Aspartate (immunology), Recurrence.
- MESH :
- chemical , blood : Autoantibodies.
- blood : Anti-N-Methyl-D-Aspartate Receptor Encephalitis, Encephalitis, Herpes Simplex.
- immunology : Anti-N-Methyl-D-Aspartate Receptor Encephalitis, Encephalitis, Herpes Simplex, Receptors, N-Methyl-D-Aspartate.
- Adolescent, Child, Preschool, Female, Humans, Infant, Male, Recurrence.
Abstract
Herpes simplex virus encephalitis (HSVE) is a devastating condition that relapses, often with a chorea in children, despite adequate antiviral treatment. At relapse, evidence of viral replication is frequently absent, suggesting that the relapse may be immune-mediated. Seven children who had a neurological relapse following their initial encephalitis, identified from 20 cases of pediatric HSVE, were studied. Serum and/or cerebrospinal fluid (CSF) were tested for N-methyl-D-aspartate receptor (NMDAR) and other antibodies previously reported in central nervous system autoimmunity. Five of the 7 relapsing children had choreoathetosis; 2 of these were NMDAR antibody-positive, 2 were negative (1 with HSV-positive CSF), and 1 was not available for testing. An additional patient, who relapsed with cognitive regression but with no movement disorder, was also NMDAR antibody-positive. In 2 of the NMDAR antibody-positive patients who were treated at relapse and in 1 who was treated only after 10 years of having a relapsing encephalopathy, a beneficial response was observed. Neurological relapses after HSVE may frequently be immune-mediated, particularly in children with chorea. NMDAR antibodies are common, and immunotherapy may be beneficial.
DOI: 10.1002/mds.25626
PubMed: 24014096
Affiliations:
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Le document en format XML
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Lim</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24014096</idno><idno type="pmid">24014096</idno><idno type="doi">10.1002/mds.25626</idno><idno type="wicri:Area/PubMed/Corpus">000778</idno><idno type="wicri:Area/PubMed/Curation">000778</idno><idno type="wicri:Area/PubMed/Checkpoint">000512</idno><idno type="wicri:Area/Ncbi/Merge">003D18</idno><idno type="wicri:Area/Ncbi/Curation">003D18</idno><idno type="wicri:Area/Ncbi/Checkpoint">003D18</idno><idno type="wicri:Area/Main/Merge">000504</idno><idno type="wicri:Area/Main/Curation">000504</idno><idno type="wicri:Area/Main/Exploration">000504</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">N-methyl-D-aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse.</title><author><name sortKey="Hacohen, Yael" sort="Hacohen, Yael" uniqKey="Hacohen Y" first="Yael" last="Hacohen">Yael Hacohen</name><affiliation wicri:level="4"><nlm:affiliation>Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Deiva, Kumaran" sort="Deiva, Kumaran" uniqKey="Deiva K" first="Kumaran" last="Deiva">Kumaran Deiva</name></author><author><name sortKey="Pettingill, Phillipa" sort="Pettingill, Phillipa" uniqKey="Pettingill P" first="Phillipa" last="Pettingill">Phillipa Pettingill</name></author><author><name sortKey="Waters, Patrick" sort="Waters, Patrick" uniqKey="Waters P" first="Patrick" last="Waters">Patrick Waters</name></author><author><name sortKey="Siddiqui, Ata" sort="Siddiqui, Ata" uniqKey="Siddiqui A" first="Ata" last="Siddiqui">Ata Siddiqui</name></author><author><name sortKey="Chretien, Pascale" sort="Chretien, Pascale" uniqKey="Chretien P" first="Pascale" last="Chretien">Pascale Chretien</name></author><author><name sortKey="Menson, Esse" sort="Menson, Esse" uniqKey="Menson E" first="Esse" last="Menson">Esse Menson</name></author><author><name sortKey="Lin, Jean Pierre" sort="Lin, Jean Pierre" uniqKey="Lin J" first="Jean-Pierre" last="Lin">Jean-Pierre Lin</name></author><author><name sortKey="Tardieu, Marc" sort="Tardieu, Marc" uniqKey="Tardieu M" first="Marc" last="Tardieu">Marc Tardieu</name></author><author><name sortKey="Vincent, Angela" sort="Vincent, Angela" uniqKey="Vincent A" first="Angela" last="Vincent">Angela Vincent</name></author><author><name sortKey="Lim, Ming J" sort="Lim, Ming J" uniqKey="Lim M" first="Ming J" last="Lim">Ming J. Lim</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Anti-N-Methyl-D-Aspartate Receptor Encephalitis (blood)</term><term>Anti-N-Methyl-D-Aspartate Receptor Encephalitis (immunology)</term><term>Autoantibodies (blood)</term><term>Child, Preschool</term><term>Encephalitis, Herpes Simplex (blood)</term><term>Encephalitis, Herpes Simplex (immunology)</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Receptors, N-Methyl-D-Aspartate (immunology)</term><term>Recurrence</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Autoantibodies</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Anti-N-Methyl-D-Aspartate Receptor Encephalitis</term><term>Encephalitis, Herpes Simplex</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Anti-N-Methyl-D-Aspartate Receptor Encephalitis</term><term>Encephalitis, Herpes Simplex</term><term>Receptors, N-Methyl-D-Aspartate</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Recurrence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Herpes simplex virus encephalitis (HSVE) is a devastating condition that relapses, often with a chorea in children, despite adequate antiviral treatment. At relapse, evidence of viral replication is frequently absent, suggesting that the relapse may be immune-mediated. Seven children who had a neurological relapse following their initial encephalitis, identified from 20 cases of pediatric HSVE, were studied. Serum and/or cerebrospinal fluid (CSF) were tested for N-methyl-D-aspartate receptor (NMDAR) and other antibodies previously reported in central nervous system autoimmunity. Five of the 7 relapsing children had choreoathetosis; 2 of these were NMDAR antibody-positive, 2 were negative (1 with HSV-positive CSF), and 1 was not available for testing. An additional patient, who relapsed with cognitive regression but with no movement disorder, was also NMDAR antibody-positive. In 2 of the NMDAR antibody-positive patients who were treated at relapse and in 1 who was treated only after 10 years of having a relapsing encephalopathy, a beneficial response was observed. Neurological relapses after HSVE may frequently be immune-mediated, particularly in children with chorea. NMDAR antibodies are common, and immunotherapy may be beneficial.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Oxfordshire</li></region><settlement><li>Oxford</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><noCountry><name sortKey="Chretien, Pascale" sort="Chretien, Pascale" uniqKey="Chretien P" first="Pascale" last="Chretien">Pascale Chretien</name><name sortKey="Deiva, Kumaran" sort="Deiva, Kumaran" uniqKey="Deiva K" first="Kumaran" last="Deiva">Kumaran Deiva</name><name sortKey="Lim, Ming J" sort="Lim, Ming J" uniqKey="Lim M" first="Ming J" last="Lim">Ming J. Lim</name><name sortKey="Lin, Jean Pierre" sort="Lin, Jean Pierre" uniqKey="Lin J" first="Jean-Pierre" last="Lin">Jean-Pierre Lin</name><name sortKey="Menson, Esse" sort="Menson, Esse" uniqKey="Menson E" first="Esse" last="Menson">Esse Menson</name><name sortKey="Pettingill, Phillipa" sort="Pettingill, Phillipa" uniqKey="Pettingill P" first="Phillipa" last="Pettingill">Phillipa Pettingill</name><name sortKey="Siddiqui, Ata" sort="Siddiqui, Ata" uniqKey="Siddiqui A" first="Ata" last="Siddiqui">Ata Siddiqui</name><name sortKey="Tardieu, Marc" sort="Tardieu, Marc" uniqKey="Tardieu M" first="Marc" last="Tardieu">Marc Tardieu</name><name sortKey="Vincent, Angela" sort="Vincent, Angela" uniqKey="Vincent A" first="Angela" last="Vincent">Angela Vincent</name><name sortKey="Waters, Patrick" sort="Waters, Patrick" uniqKey="Waters P" first="Patrick" last="Waters">Patrick Waters</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hacohen, Yael" sort="Hacohen, Yael" uniqKey="Hacohen Y" first="Yael" last="Hacohen">Yael Hacohen</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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